RNA and microRNAs in fragile X mental retardation
- 1 November 2004
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 6 (11) , 1048-1053
- https://doi.org/10.1038/ncb1104-1048
Abstract
Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general.Keywords
This publication has 73 references indexed in Scilit:
- Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysGenes & Development, 2004
- The mGluR theory of fragile X mental retardationTrends in Neurosciences, 2004
- The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesisDevelopmental Biology, 2004
- A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteinsGenes & Development, 2002
- Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and FunctionCell, 2001
- Identification of Mouse YB1/p50 as a Component of the FMRP-Associated mRNP ParticleBiochemical and Biophysical Research Communications, 2000
- Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term DepressionScience, 2000
- The fragile X mental retardation protein is associated with ribosomesNature Genetics, 1996
- Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradoxCell, 1991
- Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeCell, 1991