Effect of Amoxicillin with Clavulanic Acid Antibiotic Premedication on Pre-Treatment and Post-Endodontic Pain in Teeth with Irreversible Pulpitis: A Randomized. Controlled Trial

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Abstract
The purpose of this randomized, double-blind, controlled study was to assess the effect of antibiotic premedication on pre treatment and post opertive pain after endodontic treatment. Forty two patients with symptomatic irreversible pulpitis were randomized and allocated to experimental and placebo groups where the experimental group received the antibiotic premedication. Degree of pain was measured by the number of analgesics needed in addition to a four step pain scale before initiation of endodontic treatment and at time intervals of 6, 12, 24, 48 and 96 hours. We found that no statistical significant difference was detected at the pretreatment time interval. Statistical significant difference was groups after 24 hours of endodontic treatment where the experimental group reported less degree of post operative pain than the placebo group. No statistical significance difference detected at other time intervals. we concluded that antibiotic premedication could be prescribed to lessen the degree of post operative. pain after endodontic treatment

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