Heike Gampp
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Heike Gampp has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Ann-Kathrin Rahm
Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, 69120 Heidelberg, Germany
1 shared publication - Christine Mages
Department of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
1 shared publication - Dierk Thomas
Universitätsklinikum Heidelberg
1 shared publication - Florian André
Cardiology, Angiology & Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany
1 shared publication - Norbert Frey
Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, 69120 Heidelberg, Germany
1 shared publication - Pascal Syren
Department of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
1 shared publication
Latest Publications
- Open Access
Electrical Ventricular Remodeling in Dilated Cardiomyopathy
Ventricular arrhythmias contribute significantly to morbidity and mortality in patients with heart failure (HF). Pathomechanisms underlying arrhythmogenicity in patients with structural heart disease and impaired cardiac function include myocardial fibrosis and the remodeling of ion channels, affecting electrophysiologic properties of ventricular cardiomyocytes. The dysregulation of ion channel expression has been associated with cardiomyopathy and with the development of arrhythmias. However, the underlying molecular signaling pathways are increasingly recognized. This review summarizes clinical and cellular electrophysiologic characteristics observed in dilated cardiomyopathy (DCM) with ionic and structural alterations at the ventricular level. Furthermore, potential translational strategies and therapeutic options are highlighted.
Open AccessElectrical Ventricular Remodeling in Dilated Cardiomyopathy
Ventricular arrhythmias contribute significantly to morbidity and mortality in patients with heart failure (HF). Pathomechanisms underlying arrhythmogenicity in patients with structural heart disease and impaired cardiac function include myocardial fibrosis and the remodeling of ion channels, affecting electrophysiologic properties of ventricular cardiomyocytes. The dysregulation of ion channel expression has been associated with cardiomyopathy and with the development of arrhythmias. However, the underlying molecular signaling pathways are increasingly recognized. This review summarizes clinical and cellular electrophysiologic characteristics observed in dilated cardiomyopathy (DCM) with ionic and structural alterations at the ventricular level. Furthermore, potential translational strategies and therapeutic options are highlighted.