Shuhan Liu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Shuhan Liu has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Hong Huang
Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China
1 shared publication - Ji Peng
Longgang District Central Hospital of Shenzhen, Shenzhen, China
1 shared publication - Song Hu
Longgang District Central Hospital of Shenzhen, Shenzhen, China
1 shared publication - Xiao Zhong
Longgang District Central Hospital of Shenzhen, Shenzhen, China
1 shared publication - Xiaohong Huang
Department of Nursing Longgang District Central Hospital of Shenzhen Shenzhen Guangdong China
1 shared publication - Yanshan Huang
Longgang District Central Hospital of Shenzhen, Shenzhen, China
1 shared publication
Latest Publications
- 20 April 2023
- Published by Springer Nature in International Archives of Occupational and Environmental Health
- Vol. 96 (6) , 785-796
The meta-analysis of cytogenetic biomarkers as an assessment of occupational risk for healthcare workers exposed to antineoplastic drugs
Objective Antineoplastic drugs (ADs) are widely used in clinical practice and have been demonstrated to be effective in treating malignant tumors. However, they carry a risk of cytogenotoxicity for healthcare workers. Studies have reported that genotoxic biomarkers can be applied to assess the occupational health status of healthcare workers at an early stage, but results of different studies are variable. The objectives of the review were examine the association between long-term exposure to ADs and cytogenetic damage to healthcare workers. Methods We systematically reviewed studies between 2005 and 2021 using PubMed, Embase and Web of Science databases that used cytogenetic biomarkers to assess occupational exposure to ADs in healthcare workers. We used RevMan5.4 to analyze the tail length parameters of the DNA, frequency of the chromosomal aberrations, sister chromatid exchanges and micronuclei. A total of 16 studies were included in our study. The studies evaluate the quality of the literature through the Agency for Healthcare Research and Quality. Results The results revealed that under the random-effects model, the estimated standard deviation was 2.37 (95% confidence interval [CI] 0.92–3.81, P = 0.001) for the tail length parameters of the DNA, 1.48 (95% CI 0.71–2.25, P = 0.0002) for the frequency of chromosomal aberrations, 1.74 (95% CI 0.49–2.99, P = 0.006) for the frequency of sister chromatid exchanges and 1.64 (95% CI 0.83–2.45, P < 0.0001) for the frequency of micronuclei. Conclusions The results indicate that there is a significant association between occupational exposure to ADs and cytogenetic damage, to which healthcare workers should be alerted.
- 20 April 2023
- Published by Springer Nature in International Archives of Occupational and Environmental Health
- Vol. 96 (6) , 785-796
The meta-analysis of cytogenetic biomarkers as an assessment of occupational risk for healthcare workers exposed to antineoplastic drugs
Objective Antineoplastic drugs (ADs) are widely used in clinical practice and have been demonstrated to be effective in treating malignant tumors. However, they carry a risk of cytogenotoxicity for healthcare workers. Studies have reported that genotoxic biomarkers can be applied to assess the occupational health status of healthcare workers at an early stage, but results of different studies are variable. The objectives of the review were examine the association between long-term exposure to ADs and cytogenetic damage to healthcare workers. Methods We systematically reviewed studies between 2005 and 2021 using PubMed, Embase and Web of Science databases that used cytogenetic biomarkers to assess occupational exposure to ADs in healthcare workers. We used RevMan5.4 to analyze the tail length parameters of the DNA, frequency of the chromosomal aberrations, sister chromatid exchanges and micronuclei. A total of 16 studies were included in our study. The studies evaluate the quality of the literature through the Agency for Healthcare Research and Quality. Results The results revealed that under the random-effects model, the estimated standard deviation was 2.37 (95% confidence interval [CI] 0.92–3.81, P = 0.001) for the tail length parameters of the DNA, 1.48 (95% CI 0.71–2.25, P = 0.0002) for the frequency of chromosomal aberrations, 1.74 (95% CI 0.49–2.99, P = 0.006) for the frequency of sister chromatid exchanges and 1.64 (95% CI 0.83–2.45, P < 0.0001) for the frequency of micronuclei. Conclusions The results indicate that there is a significant association between occupational exposure to ADs and cytogenetic damage, to which healthcare workers should be alerted.