Hao Jiang

Epilepsy, as a common brain disease, causes great pain and stress to patients around the world. At present, the main treatment methods are drug, surgical, and electrical stimulation therapies. Electrical stimulation has recently emerged as an alternative treatment for reducing symptomatic seizures. This study proposes a novel closed-loop epilepsy detection system and stimulation control chip. A time-domain detection algorithm based on amplitude, slope, line length, and signal energy characteristics is introduced. A new threshold calculation method is proposed; that is, the threshold is updated by means of the mean and standard deviation of four consecutive eigenvalues through parameter combination. Once a seizure is detected, the system begins to control the stimulation of a two-phase pulse current with an amplitude and frequency of 34 μA and 200 Hz, respectively. The system is physically designed on the basis of the UMC 55 nm process and verified by a field programmable gate array verification board. This research is conducted through innovative algorithms to reduce power consumption and the area of the circuit. It can maintain a high accuracy of more than 90% and perform seizure detection every 64 ms. It is expected to provide a new treatment for patients with epilepsy.

Radio frequency identification (RFID) tags are widely used in various electronic devices due to their low cost, simple structure, and convenient data reading. This topic aims to study the key technologies of ultra-high frequency (UHF) RFID tags and high-precision temperature sensors, and how to reduce the power consumption of the temperature sensor and the overall circuits while maintaining minimal loss of performance. Combined with the biomedicine, an innovative high-precision human UHF RFID chip for body temperature monitoring is designed. In this study, a ring oscillator whose output frequency is linearly related to temperature is designed and proposed as a temperature-sensing circuit by innovatively combining auxiliary calibration technology. Then, a binary counter is used to count the pulses, and the temperature is ultimately calculated. We designed a relaxation oscillator independent of voltage and current. The various types of resistors were used to offset the temperature deviation. A current mirror array calibration circuit is used to calibrate the process angle deviation of the clock circuit with a self-calibration algorithm. This study mainly contributes to reducing power consumption and improving accuracy. The total power consumption of the RF/analog front-end and temperature sensor is 7.65 μW. The measurement error of the temperature sensor in the range of 0–60 °C is less than ±0.1%, and the accuracy of the output frequency of the clock circuit is ±2.5%.

Fluxgate magnetometer is an important device for weak magnetic-field measurements. By adding a large dc bias excitation current, the performances of fluxgate can be highly improved. In this article, based on the assumption of the single-domain state within the probe core wire, the quasi-static Stoner–Wohlfarth model (SW model) was used to construct a mathematic model for the output signal of the orthogonal fluxgate probe operated in fundamental mode (FM-OFG). The dynamic hysteresis loop characteristics were also considered here, and the expected first-harmonic output signal corresponding to the theoretical analysis was obtained from our model. A prototype FM-OFG probe was fabricated by using a 20 mm-long Co–Fe–Nb–Si–B amorphous microwire as core wire and a 1500-turn solenoid as pickup coils. Output performances were analyzed at different external fields, ac excitation currents, and dc bias currents. A good agreement between the modeling results and the experimental ones was found. The noise level was reduced down to 9.01 pT/rt (Hz).@.1 Hz. The simulation method and experiment results provide theoretical guidance for the subsequent design and improvement of the FM-OFG.