Longhua Sun
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Longhua Sun has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
Jianjun Tang
Respiratory Department, The First Affiliated Hospital of Nanchang University, Nanchang, P R China
1 shared publication- Sicong Jiang
Respiratory Department, The First Affiliated Hospital of Nanchang University, Nanchang, P R China
1 shared publication Yuxuan Xing
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou University, Suzhou, China
1 shared publicationZhiQian Zhao
Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
1 shared publication
Latest Publications
- 30 October 2025
- Published by Springer Nature in Microchimica Acta
- Vol. 192 (11) , 1-12
Sensitive chemiluminescent determination of CYFRA 21–1 as a lung cancer marker using PVP/NiO-supported luminol@ZIF-67-aptamer composite
A chemiluminescent aptamer sensor (CL aptasensor) is proposed for ultrasensitive determination of CYFRA21-1 as a lung cancer biomarker. The sensing mechanism of the CL aptasensor is based on the incorporation of luminol into a cobalt-based metal–organic framework (MOF), also called ZIF-67, to generate a composite of the luminol@ZIF-67. This composite was then functionalized with a CYFRA21-1 specific aptamer (luminol@ZIF-67-apt) as signal probe. ssDNA was immobilized on PVP/NiO nanocomposite, allowing hybridization with the aptamer by complementary base pairing. In the presence of CYFRA 21–1, the luminol@ZIF-67-apt/PVP/NiO-ssDNA ternary complex could be assembled and induced intense chemiluminescence emission. Under the optimized conditions, the sensor showed a broad linear detection range from 10⁻5 to 104 ng/mL, with a detection limit (LOD) of 3.7 × 10⁻5 ng/mL. Reproducibility (RSD = 3.81%) and long-term stability were observed, with signals retained to 98.22% and 97.87% over 20 and 33 days, respectively. Recovery experiments in spiked human serum samples ranged from 96.00% to 99.30%, and RSDs from 3.41% to 4.07%, indicating good stability and potential in complex biological matrices. Such a strategy holds great promise for ultrasensitive detection of CYFRA 21–1 for clinical bioanalysis. Graphical Abstract
- 30 October 2025
- Published by Springer Nature in Microchimica Acta
- Vol. 192 (11) , 1-12
Sensitive chemiluminescent determination of CYFRA 21–1 as a lung cancer marker using PVP/NiO-supported luminol@ZIF-67-aptamer composite
A chemiluminescent aptamer sensor (CL aptasensor) is proposed for ultrasensitive determination of CYFRA21-1 as a lung cancer biomarker. The sensing mechanism of the CL aptasensor is based on the incorporation of luminol into a cobalt-based metal–organic framework (MOF), also called ZIF-67, to generate a composite of the luminol@ZIF-67. This composite was then functionalized with a CYFRA21-1 specific aptamer (luminol@ZIF-67-apt) as signal probe. ssDNA was immobilized on PVP/NiO nanocomposite, allowing hybridization with the aptamer by complementary base pairing. In the presence of CYFRA 21–1, the luminol@ZIF-67-apt/PVP/NiO-ssDNA ternary complex could be assembled and induced intense chemiluminescence emission. Under the optimized conditions, the sensor showed a broad linear detection range from 10⁻5 to 104 ng/mL, with a detection limit (LOD) of 3.7 × 10⁻5 ng/mL. Reproducibility (RSD = 3.81%) and long-term stability were observed, with signals retained to 98.22% and 97.87% over 20 and 33 days, respectively. Recovery experiments in spiked human serum samples ranged from 96.00% to 99.30%, and RSDs from 3.41% to 4.07%, indicating good stability and potential in complex biological matrices. Such a strategy holds great promise for ultrasensitive detection of CYFRA 21–1 for clinical bioanalysis. Graphical Abstract