Camille Firmann
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Camille Firmann has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Elodie Monteiro
Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France
1 shared publication - José-Alain Sahel
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
1 shared publication - Lucille Lapostolle
Sorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France, France
1 shared publication - Thinhinane Boumedine
Sorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France, France
1 shared publication - Valérie Fontaine
Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France
1 shared publication
Latest Publications
- Open Access
- 19 November 2025
- Published by MDPI AG in Preprints.org
Protective Effect of PBN Against Retinal Pigmented Epithelium Apoptosis and Ferroptosis Induced by Blue-Light Damage in BALB/c Mice
Age-related macular degeneration (AMD) is a complex, multifactorial disease charac-terized by the degeneration of the retina. Blue-light damage (BLD) in BALB/c mouse has been currently used as a model of AMD. Nevertheless, the impact of blue light (BL) on RPE cell dysfunction and degeneration is not well documented. Here we report the effect of phenyl-N-tertbutylnitrone (PBN) on retinal function and structure in a model of BLD in BALB/c mice. We also describe the mechanisms involved in RPE cell degeneration and protection by PBN. One week after BL visual function was assessed by full-field scotopic and photopic electroretinogram in mice treated with PBN (50 mg/kg) or vehicle 30 min before BLD and 1h, 2.5h and 4h after. mRNA expression of RPE genes involved in in-flammation, oxidative stress, apoptosis and ferroptosis were measured by qRT-PCR. Our results demonstrate for the first time the protective effect of PBN in a mouse model of BLD. They show that BL induces oxidative stress and inflammation in the RPE of BALB/c mice and activates both apoptotic and ferroptotic pathways. Moreover, we demonstrate that PBN is able to counteract these intracellular pathways.
- 19 November 2025
- Published by MDPI AG in Preprints.org
Open AccessProtective Effect of PBN Against Retinal Pigmented Epithelium Apoptosis and Ferroptosis Induced by Blue-Light Damage in BALB/c Mice
Age-related macular degeneration (AMD) is a complex, multifactorial disease charac-terized by the degeneration of the retina. Blue-light damage (BLD) in BALB/c mouse has been currently used as a model of AMD. Nevertheless, the impact of blue light (BL) on RPE cell dysfunction and degeneration is not well documented. Here we report the effect of phenyl-N-tertbutylnitrone (PBN) on retinal function and structure in a model of BLD in BALB/c mice. We also describe the mechanisms involved in RPE cell degeneration and protection by PBN. One week after BL visual function was assessed by full-field scotopic and photopic electroretinogram in mice treated with PBN (50 mg/kg) or vehicle 30 min before BLD and 1h, 2.5h and 4h after. mRNA expression of RPE genes involved in in-flammation, oxidative stress, apoptosis and ferroptosis were measured by qRT-PCR. Our results demonstrate for the first time the protective effect of PBN in a mouse model of BLD. They show that BL induces oxidative stress and inflammation in the RPE of BALB/c mice and activates both apoptotic and ferroptotic pathways. Moreover, we demonstrate that PBN is able to counteract these intracellular pathways.