Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl.
Authors:
- L A PirritLPL A Pirrit
- J R YatesJYJ R Yates
- A E FryerAFA E Fryer
- M A Ferguson-SmithMFM A Ferguson-Smith
- 1 September 1987
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (9) , 544-546
Abstract
Linkage analysis was undertaken in six families with tuberous sclerosis (TS) using a restriction fragment length polymorphism detected by v-abl. No recombinants were observed in 13 informative meioses (four phase known) giving a maximum lod score of 3.18 at zero recombination (confidence limits 0 to 0.15). This provides further evidence for the assignment of TS to 9q34 and should facilitate cloning of the structural gene, genetic counselling, and first trimester prenatal diagnosis.Keywords
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