Effects of methylmercury on prenatal development in mice

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Abstract
Single doses (2, 4, or 8 mg/kg) of methylmercury dicyandiamide (MMD) were given ip to 129/SvS1 and A/J pregnant mice on days 6‐13 of gestation and fetuses were examined on day 15 or 18. Results indicated that MMD (1) retarded growth in both strains; (2) retarded stage of development in 129s; (3) was embryolethal and teratogenic (brain, palate, or facial defects) in 129s when administered on days 9‐13 but not on days 6‐8; (4) was not embryolethal in As; and (5) was teratogenic (palate and jaw defects) in As when injected on days 9‐13. All of the quantities measured were found to vary with day of treatment, dose, and strain.

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