Nanoparticles in Cancer Therapy: Current Progress, Challenges, and Future Perspectives in Clinical Translation
Open Access
- 31 December 2024
- journal article
- Published by Research Lake International Inc. in International Journal of Advanced Nano Computing and Analytics
- Vol. 3 (2) , 68-79
Abstract
Cancer treatment is evolving with the advent of nanotechnology, shifting from conventional therapies to precision medicine. Nanoparticles (1–100 nm) which encapsulate drugs and direct them to tumor sites offer unique advantages in cancer therapy, including enhanced drug delivery, reduced toxicity, and improved specificity. This editorial examines various types of nanoparticles, with focus on those that have progressed to clinical trials, while addresses the challenges in translating these innovations from the laboratory to clinical practice. Despite the growing body of researNanoparticlesch, the number of approved nanodrugs remains limited. Hence a deeper understanding of nano formulations and their targeting mechanisms will be crucial to advancing cancer treatment in the future.Keywords
This publication has 73 references indexed in Scilit:
- Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapyMedical Physics, 2020
- Liposomal Irinotecan: A Review in Metastatic Pancreatic AdenocarcinomaDrugs, 2020
- Sequence‐Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable AssembliesAngewandte Chemie International Edition, 2020
- Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and NailsAmerican Journal of Clinical Dermatology, 2018
- Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In VivoAdvanced Science, 2018
- A degradable triple temperature‐, pH‐, and redox‐responsive drug system for cancer chemotherapyJournal of Biomedical Materials Research Part A, 2018
- Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristineCancer Chemotherapy and Pharmacology, 2012
- In vitro assessments of nanomaterial toxicityAdvanced Drug Delivery Reviews, 2009
- Active targeting schemes for nanoparticle systems in cancer therapeuticsAdvanced Drug Delivery Reviews, 2008
- Drug Targeting in Cancer Chemotherapy: A Clinical PerspectiveJournal of Pharmaceutical Sciences, 1990