FURTHER STUDIES ON THE EFFECTS OF OESTROGENS AND ANTI-OESTROGENS ON EARLY PREGNANCY IN MICE

Authors:
  • LML. Martin
    L. Martin
  • RCR. I. Cox
    R. I. Cox
  • CEC. W. Emmens
    C. W. Emmens
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Abstract
Summary.: A number of synthetic anti-oestrogens have been shown to interrupt early pregnancy in mice. It is not clear, however, whether they do so by reason of their anti-oestrogenic or pro-oestrogenic activity since, in the series tested, both properties are highly correlated with the effectiveness of the compounds in interrupting pregnancy. An experiment involving the simultaneous administration of dimethylstilboestrol (dms) and oestradiol-3 : 17β failed to clarify this situation.