PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia
Authors:
- 1 September 2020
- journal article
- research article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 201, 112411
Abstract
No abstract availableKeywords
Funding Information
- NSERC (RGPIN-2014-05767)
- CIHR (MOP-130424, MOP-137036, 950-232042)
- Canada Research Chair
- Canadian Cancer Society
- Canadian Breast Cancer Foundation (703963, 705456)
- Leukaemia and Lymphoma Society of Canada and infrastructure grants (33536)
- Ontario Research Foundation (34876)
This publication has 38 references indexed in Scilit:
- Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myelomaBlood, 2012
- Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymesCurrent Opinion in Structural Biology, 2011
- Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin AJournal of the American Chemical Society, 2010
- The many roles of histone deacetylases in development and physiology: implications for disease and therapyNature Reviews Genetics, 2009
- Development of a fluorescence polarization based assay for histone deacetylase ligand discoveryBioorganic & Medicinal Chemistry Letters, 2008
- Histone Deacetylase 6 Regulates Growth Factor-Induced Actin Remodeling and EndocytosisMolecular and Cellular Biology, 2007
- Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cellsInternational Journal of Cancer, 2007
- A Metabolic Screening Study of Trichostatin A (TSA) and TSA-Like Histone Deacetylase Inhibitors in Rat and Human Primary Hepatocyte CulturesThe Journal of Pharmacology and Experimental Therapeutics, 2007
- Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical ImplicationMolecular and Cellular Biology, 2005
- The history of cancer epigeneticsNature Reviews Cancer, 2004