Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis

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Abstract
Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.
Funding Information
  • Instituto de Salud Carlos III, Spanish Government (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Fondo Europeo de Desarrollo Regional (FEDER) (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Health Department of Catalonia (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Progress and Health Foundation of the Andalusian Regional Ministry of Health (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Obra Social la Caixa (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Obra Social Sant Joan de Déu, BML (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • Departament d’Economia i Coneixement de la Generalitat de Catalunya (Spain) (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • ministerio de ciencia e innovacion (spain) (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)
  • CIBER (PI11/01347, PI14/00044, PI18/00212, PI-0634/2011, PI-0193/2014, RTI2018-100927-J-I00, PID2019-104830RB-I00)

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