Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
Open Access
- 4 June 2021
- journal article
- review article
- Published by Springer Nature in Journal of Biomedical Science
- Vol. 28 (1) , 1-14
Abstract
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including development, differentiation, inflammation, thermogenesis, neuronal and cerebral physiology, and the maintenance of stemness in stem cells. LSD1 also participates in pathological processes, including cancer as the most representative disease. It promotes oncogenesis by facilitating the survival of cancer cells and by generating a pro-cancer microenvironment. In this review, we discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of cancer stem cells, as well as anti-tumor immunity. Additionally, the current understanding of the involvement of LSD1 in various other pathological processes is discussed.Keywords
Funding Information
- National Research Foundation of Korea (2017R1A3B1023387, 2016R1A5A1011974, NRF-2019R1C1C1004022)
This publication has 118 references indexed in Scilit:
- Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturationeLife, 2013
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem CellsCancer Cell, 2012
- Monocyte trafficking in acute and chronic inflammationTrends in Immunology, 2011
- Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST ComplexStructure, 2011
- Snail1 links transcriptional control with epigenetic regulationThe EMBO Journal, 2010
- The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1The EMBO Journal, 2010
- miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition ElementsMolecular Cell, 2009
- SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during HypoxiaCell, 2007
- RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1αMolecular Cell, 2007
- Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1Cell, 2004