The Use of Antioxidants in Healing
Author:
- 1 February 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Dermatologic Surgery
- Vol. 22 (2) , 156-160
Abstract
Antioxidants enhance the healing of infected and noninfected wounds by reducing the damage caused by oxygen radicals. Studies were conducted to determine if the CTR components (vitamin E, sodium pyruvate, and specific fatty acids) could synergistically enhance healing. In vitro and in vivo studies were used to assess the effect of various combinations of CRT components. CTR reduced oxidative damage to keratinocytes and monocytes exposed to ultraviolet light and toxic chemicals and provided protection to human subjects exposed to ultraviolet irradiation. CTR dramatically facilitated healing of infected and noninfected wounds. In herpes-infected guinea pigs, CTR reduced vaginal viral lesion development, severity, and duration, thus facilitated healing of the lesions. CTR also reversed doxorubicin cytotoxicity in monocytes and reversed doxorubicin-impaired wound healing in rats. The CTR components worked synergistically to enhancing healing of injuries.Keywords
This publication has 19 references indexed in Scilit:
- Effects of Ascorbic Acid on Proliferation and Collagen Synthesis in Relation to the Donor Age of Human Dermal FibroblastsJournal of Investigative Dermatology, 1994
- Protein Oxidation and AgingScience, 1992
- Water-soluble antioxidant specificity against free radical injury using cultured human ventricular myocytes and fibroblasts and saphenous vein endothelial cellsJournal of Molecular and Cellular Cardiology, 1990
- Biochemical Evidence of Lipoperoxidation in Venous Stasis Ulcer Beneficial Role of Vitamin E as AntioxidantAnnals of the New York Academy of Sciences, 1989
- Antioxidants and multistage carcinogenesis in mouse skinFree Radical Biology and Medicine, 1989
- Oxygen toxicity and reactive oxygen metabolites in mammalsFree Radical Biology and Medicine, 1989
- Secretion of pyruvate. An antioxidant defense of mammalian cells.Journal of Experimental Medicine, 1987
- Iron and free radical reactions: two aspects of antioxidant protectionTrends in Biochemical Sciences, 1986
- The Toxicology of Molecular OxygenCRC Critical Reviews in Toxicology, 1984
- Toxic effect of X-irradiated medium on chick embryo cellsExperimental Cell Research, 1966