Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins
- 7 November 2011
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 353 (16) , 2976-2980
Abstract
The organocatalytic enantioselective decarboxylative addition of malonic acids half thioesters to isatins using a squaramide catalyst afforded the products with high enantioselectivity. These products are key intermediates in the synthesis of 3‐substituted 3‐hydroxy‐2‐oxindole derivatives. The first enantioselective synthesis of (−)‐flustraminol B has been accomplished.Keywords
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