Studies on prostaglandin antagonists

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Summary: Three prostaglandin antagonists have been examined for their ability to block PGE2 and PGF2α on human, guinea‐pig and isolated rat gastrointestinal muscle. 7‐oxa‐13‐Prostynoic acid was either a non‐selective antagonist, or was ineffective on the tissues studied; it had marked spasmogenic activity on the rat fundus. 1‐Acetyl‐2‐(8‐chloro‐10,11‐dihydrodibenz (b,f)(1,4) oxazepine‐10‐carbonyl)hydrazine selectively antagonized the excitatory effects of PGE2 and PGF2α in guinea‐pig and rat tissues, but not in human muscle. Polyphloretin phosphate selectively antagonized the excitatory effects of prostaglandins in both human and guinea‐pig muscle preparations, but it caused stimulation of the rat fundus. All the antagonists lowered the tone in many tissues. They also reduced contractions caused by potassium. None of the compounds blocked the inhibitory effect of PGE2 on intestinal circular muscle. The implication of these results on the nature of prostaglandin receptors, and the value of each compound as a prostaglandin antagonist are discussed.

This publication has 14 references indexed in Scilit: