Function of Nanos2 in the male germ cell lineage in mice
Author:
- 23 July 2010
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 67 (22) , 3815-3822
Abstract
Nanos is known as an evolutionarily conserved RNA-binding protein, the function of which is implicated in germ cell development. This includes the maintenance of both the primordial germ cells (PGCs) and germline stem cells. In mice, Nanos2 exhibits a unique feature in which its expression is induced only in the germ cells within the sexually determined male gonad. Nanos2 promotes male germ cell differentiation, while simultaneously suppressing a female program. In addition, Nanos2 is also expressed in the spermatogonial stem cells and functions as an intrinsic factor to maintain the stem cell population during spermatogenesis. Detailed cytological and biochemical analyses in embryonic male gonads in the mouse have revealed that Nanos2 localizes to the P-bodies, a center of RNA processing. It has also been shown that the Nanos2 interacts with protein components of the deadenylation complex involved in the initial step of the RNA degradation pathway.Keywords
This publication has 51 references indexed in Scilit:
- NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAsProceedings of the National Academy of Sciences, 2010
- The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproductionMolecular Human Reproduction, 2009
- Lim Homeobox Gene, Lhx8, Is Essential for Mouse Oocyte Differentiation and Survival1Biology of Reproduction, 2008
- A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in MiceMolecular Cell, 2008
- Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathwaysDevelopmental Biology, 2008
- Pumilio BindsparamRNA and Requires Nanos and Brat to Regulate Sodium Current inDrosophilaMotoneuronsJournal of Neuroscience, 2008
- Nanos2 suppresses meiosis and promotes male germ cell differentiationGenes & Development, 2008
- Abnormal Sperm in Mice Lacking the Taf7l GeneMolecular and Cellular Biology, 2007
- Tdrd1/Mtr-1 , a tudor -related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in miceProceedings of the National Academy of Sciences, 2006
- GDNF Family Receptor alpha1 Phenotype of Spermatogonial Stem Cells in Immature Mouse Testes1Biology of Reproduction, 2005