Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
Authors:
- P KisielowPKP Kisielow
- B ScottBSB Scott
- H KishiHKH Kishi
- Y UematsuYUY Uematsu
- H BlüthmannHBH Blüthmann
- H Von BoehmerHBH Von Boehmer
- 1 September 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 335 (6187) , 229-233
Abstract
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.Keywords
This publication has 22 references indexed in Scilit:
- The Developmental Biology of T LymphocytesAnnual Review of Immunology, 1988
- Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genesCell, 1987
- T cell tolerance by clonal elimination in the thymusCell, 1987
- The selection of the α,β heterodimeric T-cell receptor for antigenImmunology Today, 1986
- Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiencyCell, 1986
- Transfer of specificity by murine α and β T-cell receptor genesNature, 1986
- The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.Journal of Experimental Medicine, 1978
- On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?Journal of Experimental Medicine, 1978
- In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cellsNature, 1977
- A rapid method for the isolation of functional thymus‐derived murine lymphocytesEuropean Journal of Immunology, 1973