Complex Relationship between Iron Oxide Nanoparticle Degradation and the Signal Intensity in Magnetic Particle Imaging

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Abstract
Magnetic particle imaging (MPI), using superparamagnetic nanoparticles as an imaging tracer, is touted as a quantitative biomedical imaging technology, but MPI signal properties have never been characterized for magnetic nanoparticles undergoing biodegradation. We show that MPI signal properties can increase or decrease as iron oxide nanoparticles degrade, depending on the nanoparticle formulation and nanocrystal size and the degradation rate and mechanism. Further, we show that long-term in vitro MPI experiments only roughly approximate long-term in vivo MPI signal properties. Further, we demonstrate, for the first time, an environmentally sensitive MPI contrast mechanism, opening the door to smart contrast paradigms in MPI.
Funding Information
  • Michigan Economic Development Corporation (Tech Transfer Talent Network (T3N) program)

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