A Highly Efficient Approach for the Synthesis of Cationic Lipid DOSPA

Authors:
  • THTimothy D. Heath
    Timothy D. Heath
  • YLYanhong Li
    Yanhong Li
  • RDRobert J. Debs
    Robert J. Debs
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Abstract
A highly efficient strategy has been developed for the synthesis of the cationic lipid, N-[2-({2,5-bis[(3-aminopropyl)amino]-1-oxopentyl}amino)ethyl]-N,N-dimethyl-2,3-bis[(1-oxo-9-octadecenyl)oxy] salt with hydrogen chloride (DOSPA). It involves the linkage of a cationic head group and a hydrophobic moiety in the presence of the standard coupling reagents.