Receptor-Mediated Internalization of Fluorescent Chemotactic Peptide by Human Neutrophils
Authors:
- 28 September 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4413) , 1412-1414
Abstract
Tetramethylrhodamine labeled N -formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37°C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formyl peptide chemotactic receptor.Keywords
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