Activity based checkpoints ensure circuit stability in the olfactory system
Preprint
Abstract
Olfactory circuits function at birth, yet are continuously remodeled through the integration of adult-born interneurons into the olfactory bulb in a manner that preserves olfactory perceptual stability throughout adult life. The mechanisms that ensure appropriate circuit stability in this dynamic context remain poorly understood. Since interneurons sculpt the excitatory output of mitral and tufted (MT) neurons to the olfactory cortex, we predicted that MT neurons might instruct interneuron wiring in the adult brain. By blocking synaptic transmission from MT neurons we show that MT neuronal activity is critical to maintain olfactory bulb integrity and interneuron survival. Blocking interneuron death uncovered a second activity-dependent checkpoint regulating dendrite branching. In contrast, cortical circuits and MT neurons remain stable in the face of these silent and degenerating olfactory circuits. These studies identify a circuit-specific role for non-sensory activity in regulating integration of neurons into the adult brain, as predicted by previous computational models.Keywords
This publication has 47 references indexed in Scilit:
- Neurotransmitter Release at the Thalamocortical Synapse Instructs Barrel Formation But Not Axon Patterning in the Somatosensory CortexJournal of Neuroscience, 2012
- Wiring visual circuits, one eye at a timeNature Neuroscience, 2012
- Distinct representations of olfactory information in different cortical centresNature, 2011
- Cortical representations of olfactory input by trans-synaptic tracingNature, 2010
- Genetically Increased Cell-Intrinsic Excitability Enhances Neuronal Integration into Adult Brain CircuitsNeuron, 2010
- A Critical Period for Activity-Dependent Synaptic Development during Olfactory Bulb Adult NeurogenesisJournal of Neuroscience, 2009
- Defining the Human Deubiquitinating Enzyme Interaction LandscapeCell, 2009
- Divalent Cations Slow Activation of EAG Family K+ Channels through Direct Binding to S4Biophysical Journal, 2009
- V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during WalkingNeuron, 2008
- Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus in catsJournal of Comparative Neurology, 2006