Ouabain-Sensitive and-Insensitive ATPase Activities in the Kidney and the Liver of Spontaneously Hypertensive Rats

Authors:
  • MBMc. Biol
    Mc. Biol
  • MVM. Vincent
    M. Vincent
  • JSJ. Sassard
    J. Sassard
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Abstract
Ouabain-sensitive and -insensitive ATPase activities were measured in the kidneys and the liver of male and female rats of the Lyon hypertensive (LHS) and Lyon normotensive strain (LNS). At the age of 48 .+-. 2 wk, hypertensive rats showed a significantly higher blood pressure and body weight than age-matched normotensive rats. Ouabain-insensitive ATPase activity was decreased in the kidney, but not in the liver of hypertensive rats compared to normotensive rats. Ouabain-sensitive ATPase activity was non-significantly decreased in the kidney of hypertensive rats.

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