SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome
Authors:
- Sho ShibataSSSho Shibata
- Kazuhisa ChonabayashiKCKazuhisa Chonabayashi
- Hirofumi NakamuraHNHirofumi Nakamura
- Yasuko MatsumuraYMYasuko Matsumura
- Hiroki KawaharaHKHiroki Kawahara
- Yoshio OkamotoYOYoshio Okamoto
- Shohei YamamotoSYShohei Yamamoto
- Misato NishikawaMNMisato Nishikawa
- Yotaro OchiYOYotaro Ochi
- Yuri UchiyamaYUYuri Uchiyama
- Yukiko OhYOYukiko Oh
- Akitsu HottaAHAkitsu Hotta
- 7 August 2026
- journal article
- Published by Springer Nature in Leukemia
- Vol. 40 (11) , 2416-2429
Abstract
No abstract availableFunding Information
- Japan Society for the Promotion of Science (JP24K11514)
- Japan Society for the Promotion of Science (JP25K23871)
- Japan Society for the Promotion of Science (JP23K07229)
- Japan Society for the Promotion of Science (JP24K02230)
- Japan Agency for Medical Research and Development (JP19cm0106235)
- Japan Agency for Medical Research and Development (JP20bm0804027)
- Japan Agency for Medical Research and Development (JP25ek0109674)
- Japan Agency for Medical Research and Development (JP25ek0109760)
- Japan Agency for Medical Research and Development (JP25ek0109617)
- Japan Agency for Medical Research and Development (JP25ek0109648)
- Japan Agency for Medical Research and Development (JP25ek0109677)
- Japan Agency for Medical Research and Development (JP19cm0106235)
- Japan Agency for Medical Research and Development (JP20bm0804027)
- Japan Agency for Medical Research and Development (JP23bm1323001)
- Kobayashi Foundation for Cancer Research
- Fujiwara Memorial Foundation Japanese Society of Hematology
- Takeda Science Foundation
- Yasuda Memorial Medical Foundation
- Daiichi Sankyo Foundation of Life Science
- Fondation Leducq (18CVD05)
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