Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression
Authors:
- Zindel V. SegalZSZindel V. Segal
- Peter BielingPBPeter Bieling
- Trevor YoungTYTrevor Young
- Glenda MacQueenGMGlenda MacQueen
- Robert CookeRCRobert Cooke
- Lawrence MartinLMLawrence Martin
- Richard BlochRBRichard Bloch
- Robert D. LevitanRLRobert D. Levitan
Open Access
- 1 December 2010
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 67 (12) , 1256-1264
Abstract
Relapse and recurrence after recovery from major depressive disorder (MDD) are common and debilitating outcomes that carry enormous personal, familial, and societal costs.1 Maintenance antidepressant monotherapy (M-ADM), the current standard for depressive relapse prophylaxis,2 is effective as long as it is continued, but in practice this plan is compromised by rates of patient nonadherence that can reach 40%.3,4 Alternatives to long-term antidepressant monotherapy, especially those that address mood outcomes in a broader context of well-being, may appeal to patients wary of continued intervention.Keywords
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