Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: Discovery, taxonomy, activity and structure elucidation.

Authors:
  • SCSiegfried B. Christensen
    Siegfried B. Christensen
  • HAH. S. Allaudeen
    H. S. Allaudeen
  • MBMichael R. Burke
    Michael R. Burke
  • SCSteven A. Carr
    Steven A. Carr
  • SCS. K. Chung
    S. K. Chung
  • PDPeter Dephillips
    Peter Dephillips
  • JDJohn J. Dingerdissen
    John J. Dingerdissen
  • MDMichael Dipaolo
    Michael Dipaolo
  • AGAlbert J. Giovenella
    Albert J. Giovenella
  • SHSarah L. Heald
    Sarah L. Heald
  • LKLewis B. Killmer
    Lewis B. Killmer
  • BMBruce A. Mico
    Bruce A. Mico
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Abstract
An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species designated Actinomadura parvosata. Fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. Structures for seven of the isolated components were derived from a combination of mass spectral, high-field NMR and chemical techniques. The O-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of this class of antibiotics. The parvodicins are active in vitro against a range of Gram-positive bacteria. The most active parvodicin, C1, produces high serum levels in vivo [mice] and has the potential for a long duration of action.

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