HOW DOES LITHIUM WORK ON MANIC DEPRESSION? Clinical and Psychological Correlates of the Inositol Theory
Authors:
- 1 February 1996
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 47 (1) , 47-56
Abstract
▪ Abstract How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.Keywords
This publication has 18 references indexed in Scilit:
- Modulation by inositol of cholinergic-and serotonergic-induced seizures in lithium-treated ratsBrain Research, 1995
- High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithiumPharmacology Biochemistry and Behavior, 1994
- Lithium dosage and inositol levelsThe British Journal of Psychiatry, 1994
- Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depressionBiological Psychiatry, 1993
- Inositol treatment raises CSF inositol levelsBrain Research, 1993
- Dose-response and time curve of inositol prevention of Li-pilocarpine seizuresEuropean Neuropsychopharmacology, 1993
- Inositol 6 g daily may be effective in depression but not in schizophreniaHuman Psychopharmacology: Clinical and Experimental, 1993
- The effect of inositol on lithium‐induced polyuria—polydipsia in rats and humansHuman Psychopharmacology: Clinical and Experimental, 1992
- Neural and developmental actions of lithium: A unifying hypothesisCell, 1989
- High-dose dietarymyo-inositol supplementation does not alter the ischaemia phenomenon in human diabeticsActa Neurologica Scandinavica, 1989