VITAMIN D 3 -STIMULATED TEMPLATE ACTIVITY OF CHROMATIN FROM RAT INTESTINE
Authors:
- 1 June 1969
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 63 (2) , 528-531
Abstract
Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D(3) is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.Keywords
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