Animal models of necrotizing enterocolitis: review of the literature and state of the art
Authors:
Open Access
- 10 March 2018
- journal article
- review article
- Published by Walter de Gruyter GmbH in Innovative Surgical Sciences
- Vol. 3 (2) , 87-92
Abstract
Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal surgical emergency in preterm neonates. Over the last five decades, a variety of experimental models have been developed to study the pathophysiology of this disease and to test the effectiveness of novel therapeutic strategies. Experimental NEC is mainly modeled in neonatal rats, mice and piglets. In this review, we focus on these experimental models and discuss the major advantages and disadvantages of each. We also briefly discuss other models that are not as widely used but have contributed to our current knowledge of NEC.Keywords
This publication has 46 references indexed in Scilit:
- Paneth cells and necrotizing enterocolitisGut Microbes, 2012
- Dextran Sodium Sulphate Colitis Mouse Model: Traps and TricksJournal of Biomedicine and Biotechnology, 2012
- An Animal Model of Necrotizing Enterocolitis (NEC) in Preterm RabbitsFetal and Pediatric Pathology, 2012
- Paneth cell ablation in the presence ofKlebsiella pneumoniaeinduces necrotizing enterocolitis (NEC)-like injury in immature murine small intestineDisease Models & Mechanisms, 2012
- Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal EpitheliumGastroenterology, 2010
- Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitisJournal of Pediatric Surgery, 2008
- Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitisSurgery, 2007
- Necrotizing enterocolitis in a neonatal piglet modelJournal of Pediatric Surgery, 1991
- An experimental study of acute neonatal enterocolitis—the importance of breast milkJournal of Pediatric Surgery, 1974
- The pathogenesis of ischemic gastroenterocolitis of the neonate: Selective gut mucosal ischemia in asphyxiated neonatal pigletsJournal of Pediatric Surgery, 1972