Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease
- 6 April 2019
- journal article
- research article
- Published by Springer Nature in Clinical and Experimental Nephrology
- Vol. 23 (8) , 1013-1021
Abstract
Previously we found that kidney tissue and urinary exosomes from patients of diabetic kidney disease showed high levels of ceruloplasmin (CP). Because CP is an acute-phase protein of kidney origin, it could be an early marker of many other kidney diseases. To investigate this hypothesis, we first measured urine exosomal and kidney expression of CP in non-diabetic chronic kidney disease (CKD) patients (membranous nephropathy, focal segmental glomerulosclerosis, lupus nephritis and IgA nephropathy) followed by a longitudinal study in rat passive Heymann nephritis (PHN), a model of human membranous nephropathy.Keywords
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