Iron-Catalyzed Radical Cycloaddition of 2H-Azirines and Enamides for the Synthesis of Pyrroles

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Abstract
A novel and efficient Fe-catalyzed radical cycloaddition of 2H-azirines and enamides for the synthesis of substituted pyrroles has been developed. The radical cycloaddition reaction proceeded through a conceptually new Fe(II)-catalyzed homolytic cleavage of C–N bond of 2H-azirines sequential radical cyclization with enamides. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable triaryl-substituted pyrroles in good to high yields under mild reaction conditions.
Funding Information
  • Baoji University of Arts And Sciences (ZK2018057)
  • Northwest University (334100035)
  • China Postdoctoral Science Foundation (2017M620466)
  • National Natural Science Foundation of China (21472147, 21622203)

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