Living Rat SSVEP Mapping With Acoustoelectric Brain Imaging

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Abstract
Objective: Acoustoelectric Brain Imaging (ABI) is a potential method for mapping brain electrical activity with high spatial resolution (millimeter). To resolve the key issue for eventual realization of ABI, testing that recorded acoustoelectric (AE) signal can be used to decode intrinsic brain electrical activity, the experiment of living rat SSVEP measurement with ABI is implemented. Method: A 1-MHz ultrasound transducer is focused on the visual cortex of anesthetized rat. With visual stimulus, the electroencephalogram and AE signal are simultaneously recorded with Pt electrode. Besides, with FUS transducer scanning at the visual cortex, corresponding AE signals at different spatial positions are decoded and imaged. Results: Consistent with the directly measured SSVEP, decoded AE signal presents a clear event-related spectral perturbation (ERSP). And, decoded AE signal is of high amplitude response at the base and harmonics of the visual stimulus frequency. What's more, for timing signal, a significant positive amplitude correlation is observed between decoded AE signal and simultaneously measured SSVEP. In addition, the mean SNRs of SSVEP and decoded AE signal are both significantly higher than that of background EEG. Finally, with one fixed recording electrode, the active area with an inner diameter of 1mm is located within the 4 mm×4 mm measurement region. Conclusion: Experimental results demonstrate that the millimeter-level spatial resolution SSVEP measurement of living rat is achieved through ABI for the first time. Significance: This study confirms that ABI should shed light on high spatiotemporal resolution neuroimaging.
Funding Information
  • National Key Research and Development Program of China Stem Cell and Translational Research (2017YFB1300302)
  • National Natural Science Foundation of China (81801787, 81630051)
  • China Postdoctoral Science Foundation (2018M640238)

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