Expression modes and clinical manifestations of latent membrane protein 1, Ki‐67, cyclin‐B1, and epidermal growth factor receptor in nonendemic nasopharyngeal carcinoma

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Abstract
Background: We aimed to identify clinical significance of latent membrane protein 1 (LMP1), Ki‐67, cyclin‐B1, and epidermal growth factor receptor (EGFR), in nonendemic nasopharyngeal carcinoma (NPC).Methods: The relation between expression of the markers in 45 NPC specimens and clinicopathological and survival variables was statistically analyzed.Results: LMP1 was present in 33% of the tumors, and its presence was associated with advanced nodal and disease stages. Overexpression was defined as labeling index ≥ median value for Ki‐67, ≥ 15% for cyclin‐B1, and ≥50% for EGFR, and it was displayed in 50%, 55%, and 80% of the specimens, respectively. Strong EGFR staining intensity and not overexpression of the 3 markers was the variable with statistically significant impact on treatment outcomes in terms of worse local and locoregional tumor control rates.Conclusions: Our results suggest that the evaluation of EGFR staining intensity in patients with NPC may identify a subgroup of patients with poor prognosis. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

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