Nucleophilic 5-endo-trig cyclizations of N-homoallylic sulfonamides: a facile method for the construction of pyrrolidine rings
Authors:
- 1 January 2007
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 26,p. 2698-2700
Abstract
Normally disfavored 5-endo-trig cyclizations proceed in N-homoallylsulfonamides bearing a CF3, CCl3, CO2Et or CN group at the C-3 position, via an intramolecular SN2′-type or addition reaction to construct pyrrolidine rings, even though the system allows a more favorable 5-exo-trig pathway.Keywords
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