Practical, Scalable, High-Throughput Approaches to η3-Pyranyl and η3-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction
Authors:
- Maurice D LeeMLMaurice D Lee
- Lanny S. LiebeskindLLLanny S. Liebeskind
- 3 January 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 73 (3) , 882-888
Abstract
A unified strategy for the high-throughput synthesis of multigram quantities of the η3-oxopyranyl- and η3-oxopyridinylmolybdenum complexes TpMo(CO)2(η3-oxopyranyl) and TpMo(CO)2(η3-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.Keywords
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