Energy depletion by cell proliferation sensitizes the kidney epithelial cells to injury

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Abstract
ATP depletion is a hallmark of acute kidney injury. Proliferation is instrumental to kidney repair. We show that ATP levels vary during the cell cycle and that proliferation sensitizes renal epithelial cells to superimposed injuries in vitro. More proliferation and less energy production by the mitochondria are associated with adverse outcomes in injured kidney allografts. This suggests that controlling the timing of kidney repair might be beneficial to mitigate the extent of acute kidney injury.
Funding Information
  • Société Francophone de Transplantation
  • Société Francophone de Néphrologie, Dialyse et Transplantation
  • Arthur Sachs Fellowship
  • The Monahan Foundation
  • Fondation de l'Avenir pour la Recherche Médicale Appliquée
  • Fondation pour la Recherche Médicale (40207)
  • Fulbright Association
  • Groupe Pasteur Mutualité
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (2R01DK072381)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R37DK039773)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (UH3TR002155)
  • Institut National de la Santé et de la Recherche Médicale (atip avenir 2019)
  • Philippe Foundation

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