Serial Proton MR Spectroscopic Imaging of Recurrent Malignant Gliomas after Gamma Knife Radiosurgery

Authors:
  • SNSarah J. Nelson
    Sarah J. Nelson
  • DVDaniel B. Vigneron
    Daniel B. Vigneron
  • LVLynn Verhey
    Lynn Verhey
  • MMMichael McDermott
    Michael McDermott
  • DLDavid Larson
    David Larson
  • SCSusan Chang
    Susan Chang
  • MPMichael D. Prados
    Michael D. Prados
  • WDWilliam P. Dillon
    William P. Dillon
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Abstract
BACKGROUND AND PURPOSE: The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods. The purpose of this study was to use proton MR spectroscopy to investigate serial changes in recurrent malignant gliomas after gamma knife radiosurgery to characterize tissue response to high-dose radiation.