Ruthenium(II)‐Catalyzed C–H Alkenylation of Quinones: Diversity‐Oriented Strategy for Trypanocidal Compounds
- 7 January 2019
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2019 (13) , 2344-2353
Abstract
Ruthenium(II)‐catalysis enabled C–H alkenylations of unactivated naphthoquinones for the preparation of A‐ring‐modified naphthoquinoidal compounds with activity against Trypanosoma cruzi, the parasite causing Chagas disease. The present study encompasses C–H alkenylation by weak O‐coordination by means of ruthenium(II) carboxylates. This method provided an efficient and versatile tool towards a diversity‐oriented strategy for the preparation of compounds with a relevant biological profile.Keywords
Funding Information
- Capes-Humboldt research fellowship programme for experienced researchers (88881.145517/2017-01)
- DFG (Gottfried-Wilhelm-Leibniz prize)
- CAPES and DAAD (99999.008126/2015-01)
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