A trans-Golgi network retention signal YQRL fused to ricin A chain significantly enhances its cytotoxicity
- 29 December 2003
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 313 (4) , 1053-1057
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- Modification of ricin A chain, by addition of endoplasmic reticulum (KDEL) or Golgi (YQRL) retention sequences, enhances its cytotoxicity and translocationCancer Immunology, Immunotherapy, 1998
- Toxin Entry: Retrograde Transport through the Secretory PathwayJournal of Cell Biology, 1998
- Restoration of lectin activity to a non‐glycosylated ricin B chain mutant by the introduction of a novel N‐glycosylation siteFEBS Letters, 1997
- Endocytosis and intracellular sorting of ricin and Shiga toxinFEBS Letters, 1994
- TGN38 is maintained in the trans‐Golgi network by a tyrosine‐containing motif in the cytoplasmic domain.The EMBO Journal, 1993
- Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxinExperimental Cell Research, 1991
- Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.Proceedings of the National Academy of Sciences, 1990
- Temporal separation of protein toxin translocation from processing events.Journal of Biological Chemistry, 1987
- RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes.Journal of Biological Chemistry, 1987
- Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol.Journal of Biological Chemistry, 1987