Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity
Authors:
- Oscar ValbuenaOVOscar Valbuena
- Kenneth B. MarcuKMKenneth B. Marcu
- Martin WeigertMWMartin Weigert
- Robert P. PerryRPRobert P. Perry
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 276 (5690) , 780-784
Abstract
The number of germline genes specifying the variable sequences of V.kappa.21 group of L chains was determined by saturation hybridization analysis to be 4-6. This gene multiplicyt is considerably less than the total variability in the group, indicating that .kappa.-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions.Keywords
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