Novel Stereoselective Synthesis of 7β-Methyl-Substituted 5-Androstene Derivatives
Authors:
- 21 January 2003
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (4) , 1603-1606
Abstract
The 7β-methyl-5-androstene derivatives 11a−c were prepared in good yield with high stereoselectivities starting from 3β-acetoxyandrost-5-en-17-one 4. The addition of methylmagnesium iodide to the 7-carbonyl group of 7a−c gave, after hydrolysis, two isomers 9a−c and 10a−c, which were stereoselectively deoxygenated by means of an ionic hydrogenation to afford the compounds 11a−c.Keywords
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