Theoretical studies on the alkaline hydrolysis of N‐Methylcarbamates
Author:
- 1 May 1990
- journal article
- research article
- Published by Wiley in Journal of Computational Chemistry
- Vol. 11 (4) , 524-530
Abstract
The reaction mechanisms of the alkaline hydrolysis of N‐methylcarbamates were studied using the AM1 method by assuming two possible pathways: (1) nucleophilic attack of hydroxide ion on the carbonyl carbon to give a tetrahedral complex followed by its breakdown to carbamic acid (BAC2); and (2) proton abstraction by hydroxide ion at the nitrogen atom followed by elimination of the alkoxide ion to form N‐methyl isocyanate (E1cB). Reaction coordinate analysis showed that the reaction mechanism is determined by both the stability of an intermediate and the energy barrier for elimination.Keywords
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