Facilitated Transport of Lipophilic Toxins Through Polysulfone Membrane using Albumin as a Carrier
Authors:
- Wei ShiWSWei Shi
- Fengbao ZhangFZFengbao Zhang
- Guoliang ZhangGZGuoliang Zhang
- Liqin JiangLJLiqin Jiang
- Shulan WangSWShulan Wang
- Hui XuHXHui Xu
- 15 February 2004
- journal article
- research article
- Published by Taylor & Francis in Molecular Simulation
- Vol. 30 (2-3) , 117-120
Abstract
The chloromethylated/aminated asymmetric polysulfone ultrafiltration membrane with finger pores was made by the phase inversion process. The albumin-fixed facilitated transport membrane was prepared by cross-linking bovine serum albumin (BSA) into the membrane with 1,1′-carbonyldiimidazole (CDI). It was used to remove a lipophilic toxin, bilirubin, from the simulation plasma. The experiment results showed that the transfer rate of bilirubin was obviously enhanced after fixing albumin into the high-flux asymmetric membrane. The clearance of bilirubin was 43.7%. In addition, the effect of membrane thickness on facilitated transport was discussed.Keywords
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