Antitumor-Promoting Activity of Scopadulcic Acid B, Isolated from the Medicinal Plant Scoparia dulcis L.

Authors:
  • THToshimitsu Hayashi
    Toshimitsu Hayashi
  • MAMunehisa Arisawa
    Munehisa Arisawa
  • YSYoshiko Satomi
    Yoshiko Satomi
  • AIAkio Iwashima
    Akio Iwashima
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Abstract
Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro and in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, and also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.