CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Critical immune-suppressive pathways beyond programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) require greater attention. Nectins and nectin-like molecules might be promising targets for immunotherapy, since they play critical roles in cell proliferation and migration and exert immunomodulatory functions in pathophysiological conditions. Here, we show CD155 expression in both malignant cells and tumor-infiltrating myeloid cells in humans and mice. Cd155–/– mice displayed reduced tumor growth and metastasis via DNAM-1 upregulation and enhanced effector function of CD8+ T and NK cells, respectively. CD155-deleted tumor cells also displayed slower tumor growth and reduced metastases, demonstrating the importance of a tumor-intrinsic role of CD155. CD155 absence on host and tumor cells exerted an even greater inhibition of tumor growth and metastasis. Blockade of PD-1 or both PD-1 and CTLA4 was more effective in settings in which CD155 was limiting, suggesting the clinical potential of cotargeting PD-L1 and CD155 function.
Funding Information
  • National Health and Medical Research Council (1132519)
  • National Health and Medical Research Council (1098960)
  • National Health and Medical Research Council (1078671)
  • National Health and Medical Research Council (1124690)
  • EMBO (ALTF 945-2015)
  • Naito Foundation (na)
  • Dr. Mildred Scheel Stiftung fuer Krebsforschung (na)

This publication has 48 references indexed in Scilit: