Safety and Tolerability of 514G3, a True Human Anti-Protein A Monoclonal Antibody for the Treatment of S. aureus Bacteremia

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Abstract
Background. Novel therapeutic approaches are urgently needed for the treatment of serious infections due to S. aureus. 514G3 is a True Human Monoclonal antibody (IgG3), targeting Staphylococcus Protein A (SpA), which was isolated and cloned from a healthy human donor. Treatment of S. aureus infection with a True Human Antibody is expected to be safe, with minimal side effects.