Influence of Periodicity of Eating on the Activity of Various Enzymes in Adipose Tissue, Liver and Muscle of the Rat

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Abstract
The activities of various enzymes involved in the conversion of glucose to lipid were compared in tissues of meal-fed (access to food limited to a single daily 2-hour period) and nibbling (fed ad libitum) rats. Activities of hexokinase, pyruvate kinase, α-glycerophosphate dehydrogenase, acetyl CoA carboxylase and pyruvate carboxylase were significantly elevated in adipose tissue of meal-fed, as compared with nibbling rats. Muscle hexokinase activity, liver pyruvate carboxylase, and liver phosphoenolpyruvate carboxykinase activities were also enhanced by meal-feeding. The activities of liver glucokinase, hexokinase, pyruvate kinase, α-glycerophosphate dehydrogenase and acetyl CoA carboxylase, of muscle pyruvate kinase and α-glycerophosphate dehydrogenase, and of adipose tissue phosphoenolpyruvate carboxykinase were similar in meal-fed and nibbling animals. The possible significance of these observations to the metabolic economy of the meal-fed rat is discussed.

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