Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype
Authors:
- 1 November 2011
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 21 (22) , 6739-6745
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptorBioorganic & Medicinal Chemistry Letters, 2011
- Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonistsBioorganic & Medicinal Chemistry Letters, 2011
- Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4The FASEB Journal, 2010
- Sphingosine 1-Phosphate-Metabolizing Enzymes Control Influenza Virus Propagation and Viral CytopathogenicityJournal of Virology, 2010
- S1P(1) receptor agonists: Assessment of selectivity and current clinical activity.2010
- Drug Design, in Vitro Pharmacology, and Structure−Activity Relationships of 3-Acylamino-2-aminopropionic Acid Derivatives, a Novel Class of Partial Agonists at the Glycine Site on theN-Methyl-d-aspartate (NMDA) Receptor ComplexJournal of Medicinal Chemistry, 2009
- When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer TherapyCancer Research, 2009
- Sphingosine-1-phosphate and modulation of vascular toneCardiovascular Research, 2009
- Lysophospholipid Receptors in the Nervous SystemNeurochemical Research, 2002
- Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor AgonistsScience, 2002