Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer

Authors:
  • CCConstance Cirrincione
    Constance Cirrincione
  • IHI. Craig Henderson
    I. Craig Henderson
  • MCMarc L. Citron
    Marc L. Citron
  • DBDaniel R. Budman
    Daniel R. Budman
  • LGLori J. Goldstein
    Lori J. Goldstein
  • SMSilvana Martino
    Silvana Martino
  • EPEdith A. Perez
    Edith A. Perez
  • HMHyman B. Muss
    Hyman B. Muss
  • CHClifford Hudis
    Clifford Hudis
  • EWEric P. Winer
    Eric P. Winer

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Abstract
Great strides have been made in the treatment of early stage breast cancer. In patients with hormone-sensitive tumors, tamoxifen reduces the risk of recurrence and death by more than 30%.1 Moreover, treatment with aromatase inhibitors in place of or sequentially with tamoxifen further reduces the risk of recurrence in postmenopausal women with estrogen-receptor (ER)–positive tumors.2-4

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